How the body defends itself: immunity, vaccines and antibiotics
Grade 9 Science Worksheet - Building Confidence

Circle the best answer.
Ari reads a map of the body's defenses. Box X is the first line, a barrier at the body surface. What is box X?
- Memory cells, cells kept after a response
- Skin and mucus, barriers at the body surface
- Phagocytes, cells that engulf microbes
- Antibodies, proteins that match one antigen
Bo reads the map of the body's defenses. Box Y holds second-line cells that engulf and digest microbes. What is box Y?
Map of the body's defenses (model, not to scale). Arrows, each marked with what it carries: microbe to skin and mucus, meets a barrier; skin and mucus to inflammation and fever, a microbe gets past; inflammation and fever to box Y, calls in; box Y to T cells, shows antigen pieces; T cells to B cells, sends an activation signal; B cells to antibodies, make; B cells to memory cells, some become. Map of the body's defenses (model, not to scale). Arrows, each marked with what it carries: microbe to skin and mucus, meets a barrier; skin and mucus to inflammation and fever, a microbe gets past; inflammation and fever to box Y, calls in; box Y to T cells, shows antigen pieces; T cells to B cells, sends an activation signal; B cells to antibodies, make; B cells to memory cells, some become. Map of the body's defenses model, not to scale skin and mucus inflammation and fever Y a microbe gets past calls in microbe meets a barrier T cells shows antigen pieces B cells sends an activation signal antibodies memory cells make some become - Phagocytes, cells that engulf microbes
- B cells, cells that make antibodies
- Skin and mucus, barriers at the body surface
- T cells, specific cells that act in minutes
Esme reads the map of the body's defenses. Phagocytes show antigen pieces to box Z, which then signals B cells. What is box Z?
Map of the body's defenses (model, not to scale). Arrows, each marked with what it carries: microbe to skin and mucus, meets a barrier; skin and mucus to inflammation and fever, a microbe gets past; inflammation and fever to phagocytes, calls in; phagocytes to box Z, shows antigen pieces; box Z to B cells, sends an activation signal; B cells to antibodies, make; B cells to memory cells, some become. Map of the body's defenses (model, not to scale). Arrows, each marked with what it carries: microbe to skin and mucus, meets a barrier; skin and mucus to inflammation and fever, a microbe gets past; inflammation and fever to phagocytes, calls in; phagocytes to box Z, shows antigen pieces; box Z to B cells, sends an activation signal; B cells to antibodies, make; B cells to memory cells, some become. Map of the body's defenses (model, not to scale) microbe skin and mucus meets a barrier inflammation and fever a microbe gets past phagocytes calls in box Z shows antigen pieces B cells sends an activation signal antibodies make memory cells some become - Skin and mucus, barriers at the body surface
- T cells, cells that signal B cells
- Antibodies, proteins that fit any microbe
- Memory cells, cells kept after a response
Map of how a vaccine prepares the body (model, not to scale). Jun reads a map of how a vaccine prepares the body. B cells make the proteins in the blank box. What belongs in the blank box?
Map of how a vaccine prepares the body (model, not to scale). Arrows, each marked with what it carries: vaccine to phagocytes, antigen pieces; phagocytes to T cells, shows antigen pieces; T cells to B cells, sends an activation signal; B cells to the blank box, make; B cells to memory cells, some become. Map of how a vaccine prepares the body (model, not to scale). Arrows, each marked with what it carries: vaccine to phagocytes, antigen pieces; phagocytes to T cells, shows antigen pieces; T cells to B cells, sends an activation signal; B cells to the blank box, make; B cells to memory cells, some become. vaccine phagocytes T cells B cells antigen pieces shows antigen pieces sends an activation signal make memory cells some become - Antibodies, proteins that match an antigen
- Phagocytes, cells that engulf microbes
- Skin and mucus, barriers at the body surface
- Fever, a rise in body temperature
Map of the body's defenses (model, not to scale). Kira reads the map of the body's defenses. A microbe that gets past skin and mucus meets the blank box, which calls in phagocytes. What belongs there?
Map of the body's defenses (model, not to scale). Arrows, each marked with what it carries: microbe to skin and mucus, meets a barrier; skin and mucus to the blank box, a microbe gets past; the blank box to phagocytes, calls in; phagocytes to T cells, shows antigen pieces; T cells to B cells, sends an activation signal; B cells to antibodies, make; B cells to memory cells, some become. Map of the body's defenses (model, not to scale). Arrows, each marked with what it carries: microbe to skin and mucus, meets a barrier; skin and mucus to the blank box, a microbe gets past; the blank box to phagocytes, calls in; phagocytes to T cells, shows antigen pieces; T cells to B cells, sends an activation signal; B cells to antibodies, make; B cells to memory cells, some become. microbe skin and mucus phagocytes T cells B cells antibodies memory cells meets a barrier a microbe gets past calls in shows antigen pieces sends an activation signal make some become - Memory cells, cells kept after a response
- T cells, cells that signal B cells
- Inflammation and fever, second-line responses
- Antibodies, proteins that match one antigen
Map of how a vaccine prepares the body (model, not to scale). Luz reads a map of how a vaccine prepares the body. Some B cells become the blank box, which stays after the response. What belongs there?
Map of how a vaccine prepares the body (model, not to scale). Arrows, each marked with what it carries: vaccine to phagocytes, antigen pieces; phagocytes to T cells, shows antigen pieces; T cells to B cells, sends an activation signal; B cells to antibodies, make; B cells to the blank box, some become. Map of how a vaccine prepares the body (model, not to scale). Arrows, each marked with what it carries: vaccine to phagocytes, antigen pieces; phagocytes to T cells, shows antigen pieces; T cells to B cells, sends an activation signal; B cells to antibodies, make; B cells to the blank box, some become. vaccine phagocytes T cells B cells antibodies antigen pieces antigen pieces activation signal make some become - Antigen pieces, parts of a microbe
- Phagocytes, cells that engulf microbes
- Memory cells, cells that stay for next time
- Antibodies, proteins that B cells make
Two maps (model, not to scale) of the order in which defenses act on a new microbe. Milo compares two maps of the order in which defenses act on a new microbe. Which case shows the usual order?
Two maps (model, not to scale) of the order in which defenses act on a new microbe. Case P: skin and mucus, then inflammation and fever, then B cells and antibodies. Case Q: B cells and antibodies, then inflammation and fever, then skin and mucus. Two maps (model, not to scale) of the order in which defenses act on a new microbe. Case P: skin and mucus, then inflammation and fever, then B cells and antibodies. Case Q: B cells and antibodies, then inflammation and fever, then skin and mucus. Case P skin and mucus inflammation and fever B cells and antibodies Case Q B cells and antibodies inflammation and fever skin and mucus - Case Q, because specific defenses are the fastest
- Case P, because skin and mucus make the antibodies
- Case P, because barriers act first and antibodies take days
- Case Q, because antibodies are ready before any microbe arrives
Read this first
Use this
Two maps (model data, not to scale) of antibody levels after a second exposure to the same microbe, once memory cells have formed.
Noah compares two maps of a second exposure to the same microbe. Which case matches how memory cells change the response?
Two maps (model data, not to scale) of antibody levels after a second exposure to the same microbe, once memory cells have formed. Case 1: antibodies rise after 10 days and reach a peak of 20. Case 2: antibodies rise after 3 days and reach a peak of 200. Two maps (model data, not to scale) of antibody levels after a second exposure to the same microbe, once memory cells have formed. Case 1: antibodies rise after 10 days and reach a peak of 20. Case 2: antibodies rise after 3 days and reach a peak of 200. Case 1 Case 2 antibodies rise antibodies rise 10 days 3 days peak 20 peak 200 - Case 2, because a faster, higher response needs a new microbe
- Case 1, because the response is the same each time
- Case 2, because memory cells give a faster, higher response
- Case 1, because memory cells make the response slower
Antibiotic card (CDC facts)
kind of germ what CDC says about antibiotics bacteria can treat certain infections caused by bacteria viruses do not work on the viruses that cause a cold or the flu Ren reads an antibiotic card. According to the card, do antibiotics work on the viruses that cause a cold or the flu?
- No, they do not work on viruses
- Yes, if they are taken for a longer time
- Yes, they work on any kind of germ
- Yes, on the cold but not on the flu
Vaccine card (CDC facts)
vaccine form what it contains active ingredient whole microbe a weakened or inactivated microbe an antigen pieces bits of the microbe's outside or genetic material an antigen toxin a bacterial toxin made harmless an antigen Zee reads a vaccine card. According to the card, what is the active ingredient in each form of vaccine?
- Memory cells grown for the person
- Ready-made antibodies for the microbe
- An antibiotic that removes the virus
- An antigen from the microbe